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You searched for: subject:"neuroscience"
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[audio]Conférence neurosciences - JC Ameisen
Conférence dans le cadre de la journée nationale d’étude des Ceméa sur le thème "Du bon usage des neurosciences" Cette conférence de Jean-Claude Ameisen, professeur d’immunologie à l’université Paris VII, Président du Comité d’Ethique de l’INSERM, membre du Comité Consultatif National d’Ethique, a pour sujet : Quelle éthique et quelles responsabilités pour les chercheurs ?
Keywords: Neuroscience
Downloads: 576
[texts]Combining genome-scale Drosophila 3D neuroanatomical data by bridging template brains - James D. Manton
The stereotyped structure of mammalian and invertebrate brains is a crucial determinant of their circuit organization. Thus large scale efforts to map circuit organization using 3D image data are underway in a number of model systems, including flies and mice. Many of these studies use registration of sample images to a standard template brain to enable co-visualization and spatial querying. However, studies often use distinct template brains, resulting in large islands of data which cannot be d...
Keywords: Neuroscience
Downloads: 1
[texts]Spatial Information in Large-Scale Neural Recordings - Thaddeus R Cybulski
A central issue in neural recording is that of distinguishing the activities of many neurons. Here, we develop a framework, based on Fisher information, to quantify how separable a neuron's activity is from the activities of nearby neurons. We (1) apply this framework to model information flow and spatial distinguishability for several electrical and optical neural recording methods, (2) provide analytic expressions for information content, and (3) demonstrate potential applications of the appro...
Keywords: Neuroscience
Downloads: 6
[texts]Noradrenergic plasticity of olfactory sensory neuron inputs to the main olfactory bulb - Dennis Eckmeier
Sensory responses are modulated throughout the nervous system by internal factors including attention, experience, and brain state. This is partly due to fluctuations in neuromodulatory input from regions such as the noradrenergic locus coeruleus (LC) in the brainstem. LC activity changes with arousal and modulates sensory processing, cognition and memory. The main olfactory bulb (MOB) is richly targeted by LC fibers and noradrenaline profoundly influences MOB circuitry and odor-guided behavior...
Keywords: Neuroscience
Downloads: 5
[texts]Pre-trial exogenous visual flicker does not affect behavioral or EEG signatures of conflict processing - Michael X Cohen
Activity in the theta frequency band (4-8 Hz) over medial prefrontal regions has been consistently implicated in top-down cognitive control processes, including recognizing and resolving response conflict. It remains an unanswered question whether these theta-band dynamics are a neural mechanism of cognitive control, or instead are epiphenomenal to the neural computational machinery but are useful indices of brain function...
Keywords: Neuroscience
Downloads: 6
[texts]Statistical mechanics of multistable perception - Gurinder Singh Atwal
The stochastic dynamics of multistable perception poses an enduring challenge to our understanding of neural signal processing in the brain. We show that the emergence of perception switching and stability can be understood using principles of probabilistic Bayesian inference where the prior temporal expectations are matched to a scale-free power spectrum, characteristic of fluctuations in the natural environment...
Keywords: Neuroscience
Downloads: 6
[texts]Near-optimal decoding of transient stimuli from coupled neuronal subpopulations - James Trousdale
Coupling between sensory neurons impacts their tuning properties and correlations in their responses. How such coupling affects sensory representations and ultimately behavior remains unclear. We investigated the role of neuronal coupling during visual processing using a realistic biophysical model of the vertical system (VS) cell network in the blow fly. These neurons are thought to encode the horizontal rotation axis during rapid free flight manoeuvres...
Keywords: Neuroscience
Downloads: 3
[texts]Broadly tuned and respiration-independent inhibition in the olfactory bulb of awake mice - Brittany N Cazakoff
Olfactory representations are shaped by both brain state and respiration; however, the interaction and circuit substrates of these influences are poorly understood. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity that reaches the olfactory cortex via inhibition of mitral/tufted cells (MTs). GCs may potentially sparsen ensemble activity by facilitating lateral inhibition among MTs, and/or they may enforce temporally-precise activity locked to breathing...
Keywords: Neuroscience
Downloads: 9
[movies]Pentti Kanerva: Modling the brains computing with hyperdimensional computin
Guest lecture given by Pentti Kanerva for Vision Science 265 at UC Berkeley - Neural Computation
Keywords: neuroscience
Downloads: 14
[movies]Fritz Sommer: Associative memories, attractor networks and cell assemblies
Lecture by Fritz Sommer for the course Vision Science 265 - Neural Computation, at UC Berkeley.  Fritz is a member of the Redwood Center for Theoretical Neuroscience at UC Berkeley.
Keywords: neuroscience
Downloads: 33
[movies]Tony Bell: Emergence, submergence and no noise: how brains probably work
Talk by Tony Bell of the Redwood Center for Theoretical Neuroscienceat UC Berkeley.  Given to the Foundations of Mind seminar at UC Berkeley (http://foundationsofmind.org/).AbstractI explore the most likely correct idea that there is continuousinformation transfer from the micro to the macro and vice versain living systems.  I describe the mechanisms the brain uses togate these information flows (from field potentials to water andquantum) and discuss the implications for our field(s).
Keywords: neuroscience
Downloads: 56
[texts]The invariance hypothesis implies domain-specific regions in visual cortex - Joel Z. Leibo
Is visual cortex made up of general-purpose information processing machinery, or does it consist of a collection of specialized modules? If prior knowledge, acquired from learning a set of objects is only transferable to new objects that share properties with the old, then the recognition system's optimal organization must be one containing specialized modules for different object classes. Our analysis starts from a premise we call the invariance hypothesis: that the computational goal of the ve...
Keywords: Neuroscience
Downloads: 5
[texts]The micron-scale structural organization of hippocampal area CA1 neuropil - Yuriy Mishchenko
Various structures in the brain contain many important clues to the brains development and function. Among these, the organization of neuropil tissue at micron scales is of particular importance since such organization has a direct potential to affect the formation of synaptic connectivity between nearby axons and dendrites, thus, serving as an important factor contributing to the brains development and disorders...
Keywords: Neuroscience
Downloads: 7
[texts]Functional knockout of forebrain protein 14-3-3 disrupts conditioned taste aversion learning - Adam Kimbrough
Protein 14-3-3 isoforms are key to many cellular processes and are ubiquitous throughout the brain. 14-3-3 is a regulator of ser/thr phospho-signaling by binding and sequestering phosphorylated substrates including kinases, histone deactylases, and transcription factors. The role of protein 14-3-3 in conditioned taste aversion learning (CTA) has not previously been examined. We parameterized CTA learning in difopein- YFP transgenic mice, which have widespread by expression of the artificial pept...
Keywords: Neuroscience
Downloads: 5
[texts]Optimizing Real Time fMRI Neurofeedback for Therapeutic Discovery and Development - Luke Stoeckel
While reducing the burden of brain disorders remains a top priority of organizations like the World Health Organization and National Institutes of Health (BRAIN, 2013), the development of novel, safe and effective treatments for brain disorders has been slow. In this paper, we describe the state of the science for an emerging technology, real time functional magnetic resonance imaging (rtfMRI) neurofeedback, in clinical neurotherapeutics...
Keywords: Neuroscience
Downloads: 9
[texts]Neuronal control of locomotor handedness in Drosophila - Sean M Buchanan
Handedness in humans–better performance using either the left or right hand–is personally familiar, moderately heritable, and regulated by many genes, including those involved in general body symmetry. But behavioral handedness, i.e. lateralization, is a multifaceted phenomenon. For example, people display clockwise or counter- clockwise biases in their walking behavior that is uncorrelated to their hand dominance, and lateralized behavioral biases have been shown in species as disparate as ...
Keywords: Neuroscience
Downloads: 12
[texts]A high resolution 7-Tesla resting-state fMRI test-retest dataset with cognitive and physiological measures - Krzysztof Jacek Gorgolewski
Here we present a test-retest dataset of functional magnetic resonance imaging (fMRI) data acquired at rest. 22 participants were scanned during two sessions spaced one week apart. Each session includes two 1.5 mm isotropic whole-brain scans and one 0.75 mm isotropic scan of the prefrontal cortex, giving a total of six timepoints. Additionally, the dataset includes measures of mood, sustained attention, blood pressure, respiration, pulse, and the content of self-generated thoughts (mind wanderin...
Keywords: Neuroscience
Downloads: 18
[texts]Boymaw, Overexpressed in Brains with Major Psychiatric Disorders, May Encode a Small Protein to Inhibit Mitochondrial Function and Protein Translation - Baohu Ji
The t(1,11) chromosome translocation co-segregates with major psychiatric disorders in a large Scottish family. The translocation disrupts the DISC1and Boymaw (DISC1FP1) genes on chromosomes 1 and 11, respectively. After translocation, two fusion genes are generated. Our recent studies found that the DISC1-Boymaw fusion protein is localized in mitochondria and inhibits oxidoreductase activity, rRNA expression, and protein translation...
Keywords: Neuroscience
Downloads: 5
[movies]Bruno Olshausen: UC Berkeley Vision Science 265 lecture
Lecture by Bruno Olshausen, of the Redwood Center for Theoretical Neuroscience for Vision Science 265 - neural computation.
Keywords: neuroscience
Downloads: 72
[movies]Dean Buonomano: State-dependent Networks: Timing and Computations Based on Neural Dynamics and Short-term Plasticity
Talk by Dean Buonomano from UCLA.  Given to the Redwood Center for Theoretical Neuroscience at UC Berkeley.AbstractThe brain’s ability to seamlessly assimilate and process spatial and temporal information is critical to most behaviors, from understanding speech to playing the piano. Indeed, because the brain evolved to navigate a dynamic world, timing and temporal processing represent a fundamental computation...
Keywords: neuroscience
Downloads: 120
[texts]Neuroanatomical diversity of corpus callosum and brain volume in the Autism Brain Imaging Data Exchange (Abide) project - Aline Lefebvre
The corpus callosum -- the main pathway for long-distance inter-hemispheric integration in the human brain -- has been frequently reported to be smaller among autistic patients compared with non-autistic controls. We conducted a meta-analysis of the literature which suggested a statistically significant difference. However, the studies included were heavily underpowered: on average only 20% power to detect differences of 0.3 standard deviations, which makes it difficult to establish the reality ...
Keywords: Neuroscience
Downloads: 11
[texts]A data repository and analysis framework for spontaneous neural activity recordings in developing retina - Stephen Eglen
Background: During early development, neural circuits fire spontaneously, generating activity episodes with complex spatiotemporal patterns. Recordings of spontaneous activity have been made in many parts of the nervous system over the last 20 years, reporting developmental changes in activity patterns and the effects of various genetic perturbations. Results: We present a curated repository of multielectrode array recordings of spontaneous activity in developing mouse and ferret retina...
Keywords: Neuroscience
Downloads: 6
[texts]Embodied cognition, embodied regulation, and the Data Rate Theorem - Rodrick Wallace
The Data Rate Theorem carries deep implications for theories of embodied cognition, extensions providing a spectrum of necessary conditions dynamic statistical models useful in empirical studies. A large deviations argument, however, implies that the regulation and stabilization of such systems is itself an interpenetrating phenomenon necessarily convoluted with embodied cognition. For humans, the central regulatory role of culture has long been known...
Keywords: Neuroscience
Downloads: 13
[texts]Untangling cross-frequency coupling in neuroscience - Juhan Aru
Cross-frequency coupling (CFC) has been proposed to coordinate neural dynamics across spatial and temporal scales. Despite its potential relevance for understanding healthy and pathological brain function, the standard CFC analysis and physiological interpretation come with fundamental problems. For example, apparent CFC can appear because of spectral correlations due to common non-stationarities that may arise in the total absence of interactions between neural frequency components...
Keywords: Neuroscience
Downloads: 8
[texts]Genomic architecture of human neuroanatomical diversity - Roberto Toro
Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for
Keywords: Neuroscience
Downloads: 10
[texts]Detecting pairwise correlations in spike trains: an objective comparison of methods and application to the study of retinal waves. - Catherine Sarah Cutts
Correlations in neuronal spike times are thought to be key to processing in many neural systems. Many measures have been proposed to summarise these correlations and of these the correlation index is widely used and is the standard in studies of spontaneous retinal activity. We show that this measure has two undesirable properties: it is unbounded above and confounded by firing rate. We list properties needed for a measure to fairly quantify and compare correlations and we propose a novel measur...
Keywords: Neuroscience
Downloads: 8
[texts]Visual areas exert feedforward and feedback influences through distinct frequency channels - Andre M Bastos
Visual cortical areas are thought to form a hierarchy and to subserve cognitive functions by interacting in both feedforward and feedback directions. While feedforward influences convey sensory signals, feedback influences modulate brain responses to a given sensory stimulus according to the current behavioural context. Many studies have demonstrated effects of feedback influences on feedforward driven responses and on behaviour...
Keywords: Neuroscience
Downloads: 16
[texts]Local Fields of the Hippocampus: More than Meets the Eye - Gautam Agarwal
A standard methodology in systems neuroscience is to establish correlations between the brain and the world. These correlations have been robustly observed when probing the activity of single neurons. For example, there are cells that activate vigorously when subjects are presented with images of certain celebrities (e.g. the "Jennifer Aniston" neuron, Quiroga et al., 2005). While single neuron measurements provide remarkable insights into the functional specificity of different brain areas, it ...
Keywords: Neuroscience
Downloads: 7
[texts]Practopoiesis: Or how life fosters a mind - Danko Nikolic
The mind is a biological phenomenon. Thus, biological principles of organization should also be the principles underlying mental operations. Practopoiesis states that the key for achieving intelligence through adaptation is an arrangement in which mechanisms laying a lower level of organization, by their operations and interaction with the environment, enable creation of mechanisms lying at a higher level of organization...
Keywords: Neuroscience
Downloads: 6
[texts]Converging structural and functional connectivity of orbitofrontal, dorsolateral prefrontal, and posterior parietal cortex in the human striatum - Kevin Jarbo
Modification of spatial attention via reinforcement learning (Lee & Shomstein, 2013) requires the integration of reward, attention, and executive processes. Corticostriatal pathways are an ideal neural substrate for this integration because these projections exhibit a globally parallel (Alexander, De Long, and Strick, 1985), but locally overlapping (Haber, 2003), topographical organization. Here, we explored whether there are unique striatal regions that exhibit convergent anatomical connections...
Keywords: Neuroscience
Downloads: 10
[movies]Peter Loxley: The two-dimensional Gabor function adapted to natural image statistics: An analytical model of simple-cell responses in the early visual system
Talk by Peter Loxley, of the University of New Mexico, Los Alamos Campus; and Center for Nonlinear Studies, LANL.  Given to the Redwood Center for Theoretical Neuroscience at UC Berkeley.Abstract:The two-dimensional Gabor function is adapted to natural image statistics by learning the joint distribution of the Gabor function parameters. This joint distribution is subsequently modeled to yield analytically-tractable generative models of simple-cell receptive fields...
Keywords: neuroscience
Downloads: 34
[texts]General markers of conscious visual perception and their timing - Renate Rutiku
The goal of the present investigation was to identify reliable markers of conscious visual perception and to characterize their onset latency and its variability. To that end many visual stimuli from different categories were presented at near-threshold contrast and contrastive analyses were carried out on 100 balanced subsets of the data. N200 and P300 were the two reliable markers of conscious perception common to all perceived stimuli and absent for all nonperceived stimuli...
Keywords: Neuroscience
Downloads: 8
[movies]Stuart Hammeroff: Treating mental states through microtubule vibrations
Talk by Stuart Hammeroff, University of Arizona, Tucson.  Given to the Redwood Center for Theoretical Neuroscience at UC Berkeley.Abstract:Do mental states derive entirely from brain neuronal membrane activities? Neuronal interiors are organized by microtubules (‘MTs’), protein polymers proposed to encode memory, process information and support consciousness. Using nanotechnology, Bandyopadhyay’s group at MIT has shown coherent vibrations (megahertz to 10 kilohertz) from microtubule bundl...
Keywords: Neuroscience
Downloads: 91
[texts]Influence of walking speed on locomotor time production - Fabrice MEGROT
The aim of the present study was to determine whether or not walking speed affects temporal perception. It was hypothesized that fast walking would reduce the perceived length of time while slow walking increase production estimates. 16 healthy subjects were included. After a first « calibration » phase allowing the determination of different walking speeds, the subjects were instructed to demonstrate periods of time or « target times » of 3s and 7s, by a walking movement...
Keywords: Neuroscience
Downloads: 7
[movies]Siyu Zhang: Long-range and local circuits for top-down modulation of visual cortical processing
Talk by Siyu Zhang of HWNI at UC Berkeley.  Given to the Redwood Center for Theoretical Neuroscience at UC Berkeley.Abstract.Top-down modulation of sensory processing is a prominent cognitive process that allows the animal to select sensory information most relevant to the current task, but the underlying circuit mechanisms remain poorly understood. Here we show that a region of mouse frontal cortex – the cingulate cortex (Cg) – can powerfully influence sensory processing in the primary vis...
Keywords: neuroscience
Downloads: 63
[movies]Richard Axel: Order from Disorder: Representations of Olfactory Information in the Cortex
 Talk by Richard Axel from Columbia University.  Given to the Helen Wills Neuroscience Institute at UC Berkeley.  Recorded by staff from the Redwood Center for Theoretical Neuroscience at UC Berkeley.
Keywords: neuroscience
Downloads: 143
[texts]Pinwheel-dipole configuration in cat early visual cortex - Jérôme Ribot
In the early visual cortex, information is processed within functional maps whose layout is thought to underlie visual perception. However, the precise organization of these functional maps as well as their interrelationships remains unresolved. Here, we show that spatial frequency representation in cat areas 17 and 18 exhibits singularities around which the map organizes like an electric dipole potential...
Keywords: Neuroscience
Downloads: 6
[texts]Ultra fast tissue staining with chemical tags - Johannes Kohl
Genetically encoded fluorescent proteins and immunostainings are widely used to detect cellular or sub-cellular structures in thick biological samples. However, each approach suffers from limitations, including low signal and limited spectral flexibility or slow speed, poor penetration and high background, respectively. Here we overcome these limitations by using transgenically expressed chemical tags for rapid, even and low-background labeling of thick biological tissues...
Keywords: Neuroscience
Downloads: 7
[texts]Mechanisms for multiple activity modes of VTA dopamine neurons - Andrew M. Oster
Midbrain ventral segmental area (VTA) dopaminergic neurons send numerous projections to cortical and sub-cortical areas, and diffusely release dopamine (DA) to their targets. DA neurons display a range of activity modes that vary in frequency and degree of burst ring. Importantly, DA neuronal bursting is associated with a significantly greater degree of DA release than an equivalent tonic activity pattern...
Keywords: Neuroscience
Downloads: 9
[texts]Collecting reward to defend homeostasis: A homeostatic reinforcement learning theory - Mehdi Keramati
Efficient regulation of internal homeostasis and defending it against perturbations requires complex behavioral strategies. However, the computational principles mediating brain's homeostatic regulation of reward and associative learning remain undefined. Here we use a definition of primary rewards, as outcomes fulfilling physiological needs, to build a normative theory showing how learning motivated behavior is modulated by the internal state of the animal...
Keywords: Neuroscience
Downloads: 7
[movies]Matthew Wilson: Hippocampal memory reactivation during awake and sleep states - UC Berkeley HWNI seminar series
Seminar given by Matthew Wilson of MIT on September 26, 2008, for the Helen Wills Neuroscience Institute at UC Berkeley.
Keywords: Neuroscience
Downloads: 217
[texts]Bonsai: An event-based framework for processing and controlling data streams - Gonçalo Lopes
The design of modern scientific experiments requires the control and monitoring of many parallel data streams. However, the serial execution of programming instructions in a computer makes it a challenge to develop software that can deal with the asynchronous, parallel nature of scientific data. Here we present Bonsai, a modular, high-performance, open-source visual programming framework for processing data streams...
Keywords: Neuroscience
Downloads: 13
[texts]The organization and dynamics of corticostriatal pathways link the medial orbitofrontal cortex to future decisions - Timothy Verstynen
Accurately making a decision in the face of incongruent options increases the efficiency of making similar congruency decisions in the future. This adaptive process is modulated by reward, suggesting that ventral corticostriatal circuits may contribute to the process of conflict adaptation. To evaluate this possibility, a group of healthy adults (N=30) were tested using functional MRI (fMRI) while they performed a color-word Stroop task...
Keywords: Neuroscience
Downloads: 5
[texts]Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders - Baohu Ji
The t(1; 11) translocation appears to be the causal genetic lesion with 70% penetrance for schizophrenia, major depression, and other psychiatric disorders in a Scottish family. Molecular studies identified the disruption of the DISC1 (disrupted-in-schizophrenia 1) gene by chromosome translocation at chromosome 1q42. Our previous studies, however, revealed that the translocation also disrupted another gene, Boymaw (also termed DISC1FP1), on chromosome 11...
Keywords: Neuroscience
Downloads: 19
[texts]Rapid transcriptional response to physiological neuronal activity in vivo revealed by transcriptome sequencing - Yarden Katz
Neuronal activity serves as a gateway between external stimulus from environment and the brain, often inducing gene expression changes. Alternative splicing (AS) is a widespread mechanism of increasing the number of transcripts produced from a single gene and has been shown to alter properties of neuronal genes, such as ion channels and neurotransmitter receptors. Patterns of neural tissue-specific AS have been identified, often regulated by neuron-specific splicing factors that are essential fo...
Keywords: Neuroscience
Downloads: 8
[movies]Gautam Agarwal: Unsolved Mysteries of Hippocampal Dynamics
Talk by Gautam Agarwal of the Redwood Center at UC Berkeley, given to the Redwood Center as his last talk before he leaves Berkeley for Portugal.Abstract:Two radically different forms of electrical activity can be observed in the rat hippocampus: spikes and local field potentials (LFPs). Hippocampal pyramidal neurons are mostly silent, yet spike vigorously as the subject encounters particular locations in its environment...
Keywords: neuroscience
Downloads: 89
[movies]Alejandro Bujan: Propagation and variability of evoked responses: the role of correlated inputs and oscillations
Talk by Alejandro Bujan of the Bernstein Center, University of Freiburg.Given to the Redwood Center for Theoretical Neuroscience at UC Berkeley.AbstractThe cortex processes information through distributed networks of functionally heterogeneous brain areas. This processing requires spiking activity to be transferred between these different areas while preserving the information it carries. Using numerical simulations, we can study how the connectivity determines the transfer of spiking activity (...
Keywords: neuroscience
Downloads: 93
[texts]A microRNA profile in Fmr1 knockout mice reveals microRNA expression alterations with possible roles in fragile X syndrome - Ting Liu
Fragile X syndrome (FXS), a common form of inherited mental retardation, is caused by a loss of expression of the fragile X mental retardation protein (FMRP). FMRP is involved in brain functions by interacting with mRNAs and microRNAs (miRNAs) that selectively control gene expression at translational level. However, little is known about the role of FMRP in regulating miRNA expression. Here, we found a development-dependant dynamic expression of Fmr1 mRNA (encoding FMRP) in mouse hippocampus wit...
Keywords: Neuroscience
Downloads: 10
[texts]NBLAST: Rapid, sensitive comparison of neuronal structure and construction of neuron family databases - Marta Costa
Efforts to map neural circuits from model organisms including flies and mice are now generating multi-terabyte datasets of 10,000s of labelled neurons. Technologies such as dense EM based reconstruction, and sparse/multicolor labeling with image registration allow neurons to be embedded within the spatial context of a circuit or a whole brain. These ever-expanding data demand new computational tools to search, organize and navigate neurons...
Keywords: Neuroscience
Downloads: 12
[texts]Hippocampal Motifs - Zahra Aghajan
Dorsal Hippocampal neurons provide an allocentric map of space, characterized by three key properties. First, their firing is spatially selective, termed a rate code. Second, as animals traverse through place fields, neurons sustain elevated firing rates for long periods, however this has received little attention. Third the theta-phase of spikes within this sustained activity varies with animal's location, termed phase-precession or a temporal code...
Keywords: Neuroscience
Downloads: 11
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